With pathologist Eugen Albrecht, he conducted studies of coagulative necrosis.
2.
The energy delivered with each sonication is capable of raising the temperature of the tissue upwards of 65 degrees Celsius resulting in coagulative necrosis.
3.
Coagulative necrosis can also be induced by high local temperature; it is a desired effect of treatments such as high intensity focused ultrasound applied to cancerous cells.
4.
The tarry black colour is produced by the coagulative necrosis of mucosa resulting in intramucosal haemorrhage and acid hematin deposition . This condition was first described in a patient with acid poisoning.
5.
The therapeutic effect is created by raising the tissue temperature during energy delivery ( sonication ) which causes thermal ablation and defined regions of protein denaturation, irreversible cell damage and coagulative necrosis at the target.
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